Article Publish Status: FREE
Abstract Title:

Anti-Atherosclerotic Properties ofExtracts Influenced by Their Chemical Composition Associated with the Ripening Stage of the Berries.

Abstract Source:

Int J Mol Sci. 2024 Apr 9 ;25(8). Epub 2024 Apr 9. PMID: 38673738

Abstract Author(s):

Agnieszka Zielińska, Dorota Bryk, Katarzyna Paradowska, Paweł Siudem, Iwona Wawer, Małgorzata Wrzosek

Article Affiliation:

Agnieszka Zielińska


The high content of bioactive compounds infruit offers health benefits. In this study, the anti-atherosclerotic effect of Aronia extracts was assessed. The impact on the level of adhesion molecules and the inflammatory response of human umbilical vein endothelial cells (HUVECs) was shown in relation to the chemical composition and the stage of ripening of the fruits. Samples were collected between May (green, unripe) and October (red, overripe) on two farms in Poland, which differed in climate. The content of chlorogenic acids, anthocyanins, and carbohydrates in the extracts was determined using HPLC-DAD/RI. The surface expression of ICAM-1 and VCAM-1 in HUVECs was determined by flow cytometry. The mRNA levels of,,, andwere assessed using the quantitative real-time PCR method. The farms' geographical location was associated with the quantity of active compounds in berries and their anti-atherosclerotic properties. Confirmed activity for green fruits was linked to their high chlorogenic acid content.

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