Anti-breast cancer triterpenoid saponins from the thorns of Gleditsia sinensis. - GreenMedInfo Summary

One new triterpenoid saponin (), as well as six known ones (), were isolated from the ethanol extract of the thorns of. Their structures were elucidated by extensive spectroscopic analysis in conjunction with chemical evidence. Cytotoxic activity of compoundswas evaluated against human breast cancer MCF 7 cellsby the MTT method. Our results revealed moderate activities for compoundswith ICvalues of 18.43, 30.47, 18.46, 10.02, 30.76, and 17.32 μM, respectively. Furthermore, compounds,,, andinduced apoptosis in MCF 7 cell, withandcausing late apoptosis of MCF 7 cells, whileandacting oppositely.