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Abstract Title:

Anti-breast cancer triterpenoid saponins from the thorns of.

Abstract Source:

Nat Prod Res. 2019 Aug ;33(16):2308-2313. Epub 2018 Feb 23. PMID: 29473437

Abstract Author(s):

Jinqian Yu, Gang Li, Yan Mu, Honglei Zhou, Xiao Wang, Peng Yang

Article Affiliation:

Jinqian Yu

Abstract:

One new triterpenoid saponin (), as well as six known ones (), were isolated from the ethanol extract of the thorns of. Their structures were elucidated by extensive spectroscopic analysis in conjunction with chemical evidence. Cytotoxic activity of compoundswas evaluated against human breast cancer MCF 7 cellsby the MTT method. Our results revealed moderate activities for compoundswith ICvalues of 18.43, 30.47, 18.46, 10.02, 30.76, and 17.32 μM, respectively. Furthermore, compounds,,, andinduced apoptosis in MCF 7 cell, withandcausing late apoptosis of MCF 7 cells, whileandacting oppositely.

Study Type : In Vitro Study

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Sayer Ji
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