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Abstract Title:

Anti-fatigue activity of hemp leaves water extract and the related biochemical changes in mice.

Abstract Source:

Food Chem Toxicol. 2021 Apr ;150:112054. Epub 2021 Feb 10. PMID: 33577943

Abstract Author(s):

Jiaqing Zhu, Juanjuan Yi, Qiaozhen Kang, Jinyong Huang, Yan Cui, Guojun Zhang, Zongzhen Wang, Liming Zhang, Zhiqiang Zheng, Jike Lu, Limin Hao

Article Affiliation:

Jiaqing Zhu

Abstract:

To explore novel sources of anti-fatigue drugs and food, the anti-fatigue activity of hemp leaves water extract (HLWE) was investigated through exhaustive swimming tests of mice. The median exhaustion swimming time of mice gavaged with HLWE reached 55.4 min, which was 156.8% and 87.8% longer than that of the control group and Rhodiola group, respectively. Then, several biochemical parameters related to fatigue were determined to explore the possible anti-fatigue reasons. The blood lactic acid concentration of mice in HLWE group was 0.76 mmol/L,which was 24.8% lower than that in the control group. Compared with the control group, the glutathione peroxidases activity of mice in HLWE group increased by 296.2%. Based on the results, HLWE exhibited outstanding anti-fatigue activity through reducing the accumulation of lactic acid and improvingthe activities of defense antioxidant enzymes. It shows appealing potential for development and utilization as novel anti-fatigue food or drugs.

Study Type : Animal Study

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