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Article Publish Status: FREE
Abstract Title:

Anti-Fatigue Effects ofPolysaccharide and Effervescent Tablets by Regulating Oxidative Stress and Energy Metabolism in Rats.

Abstract Source:

Int J Mol Sci. 2022 Sep 18 ;23(18). Epub 2022 Sep 18. PMID: 36142831

Abstract Author(s):

Yanfeng Peng, Linlin Zhao, Ke Hu, Yongjing Yang, Jin Ma, Yuqing Zhai, Yan Jiang, Dejun Zhang

Article Affiliation:

Yanfeng Peng

Abstract:

The purpose of this study was to investigate the anti-fatigue effect of naturalpolysaccharide (LBP) during exercise, develop a functional anti-fatigue effervescent tablet by applying LBP to practical products, and help patients who have difficulty swallowing conventional tablets or capsules. LBP was extracted with water, and DEAE-52 cellulose was used for purification. The chemical structure and monosaccharide composition of LBP by Fourier transform infrared spectroscopy (FI-IR) and ion chromatography (IC).polysaccharide effervescent tablets (LBPT) were prepared by mixing LBP and an excipient. Animal experiments showed that LBP and LBPT significantly increased the exhaustive swimming time in rats. LBP and LBPT improved biochemical markers in rat serum, such as lactic acid and creatine kinase, enhanced the antioxidant capacity of rat muscle, and reversed the decrease in serum glucose, ATP and glycogen content caused by exercise. Transmission electron microscopy showed that LBP and LBPT increased the density of mitochondria in rat liver. In addition, molecular experiments showed that LBP and LBPT could improve oxidative stress caused by exercise by regulating the Nrf2/HO-1 signaling pathway and regulating energy metabolism via the AMPK/PGC-1α signaling pathway.

Study Type : Animal Study

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