n/a
Abstract Title:

Anti-HIV-1 activity of lignans from the fruits of Schisandra rubriflora.

Abstract Source:

Arch Pharm Res. 2010 May ;33(5):697-701. Epub 2010 May 29. PMID: 20512467

Abstract Author(s):

Wei-Lie Xiao, Rui-Rui Wang, Wei Zhao, Ren-Rong Tian, Shan-Zhai Shang, Liu-Meng Yang, Jian-Hong Yang, Jian-Xin Pu, Yong-Tang Zheng, Han-Dong Sun

Article Affiliation:

Wei-Lie Xiao

Abstract:

This study investigated the 70% aqueous acetone extract of the fruits of Schisandra rubriflora which led to the isolation of eight lignans, including a new isolate, rubrisandrin C (1), and seven known lignans (2-8). The structure of 1 was established by extensive 1D and 2D NMR spectroscopy and its absolute stereochemistry was determined by CD spectrum. Compounds 1-5 and 7-8 were evaluated for their anti-HIV-1 activity that showed inhibitory activity on HIV-1(IIIB) induced syncytium formation with EC(50) values in the range of 2.26 approximately 20.4 microg/mL. Compounds 1 and 7 exerted their obvious protection of HIV-1(IIIB) inducted MT-4 host cells lytic effects with a selectivity index of 15.4 and 24.6, respectively.

Study Type : In Vitro Study

Print Options


Key Research Topics

This website is for information purposes only. By providing the information contained herein we are not diagnosing, treating, curing, mitigating, or preventing any type of disease or medical condition. Before beginning any type of natural, integrative or conventional treatment regimen, it is advisable to seek the advice of a licensed healthcare professional.

© Copyright 2008-2024 GreenMedInfo.com, Journal Articles copyright of original owners, MeSH copyright NLM.