Abstract Title:

Anti-hyperuricemic and nephroprotective effects of whey protein hydrolysate in potassium oxonate-induced hyperuricemic rats.

Abstract Source:

J Sci Food Agric. 2021 Feb 4. Epub 2021 Feb 4. PMID: 33543494

Abstract Author(s):

Xiaofen Qi, Haoran Chen, Kaifang Guan, Rongchun Wang, Ying Ma

Article Affiliation:

Xiaofen Qi


BACKGROUND: Hyperuricemia (HUA) is the serious public health concern globally needs to be solved. It is closely related to gout and other metabolic diseases. To develop a safe and effective dietary supplementation for alleviating HUA, the present study investigated the effects of whey protein hydrolysate (WPH) on hyperuricemia and associated renal dysfunction, and explore their underlying mechanism.

RESULTS: Potassium oxonate (PO)-induced model rats were administered with WPH for 21 days. Results showed that WPH significantly inhibited xanthine oxidase (XOD) and adenosine deaminase (ADA) activity in serum and liver, decreased uric acid (UA), creatinine (Cr) and blood urea nitrogen (BUN) levels in serum, and increased the UA excretion in urine. In addition, WPH down-regulatedthe expression of URAT1, and up-regulated the expression of OAT1, ABCG2, OCTN1, OCTN2 and OCT1 in kidneys.

CONCLUSION: These findings demonstrated for the first time that WPH could alleviate HUA by inhibiting UA production and promoting UA excretion, and improve the renal dysfunction caused by HUA. Thus, WPH may be a potential functional ingredient for the prevention and treatment of HUA and associated renal dysfunction. This article is protected by copyright. All rights reserved.

Study Type : Animal Study

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