Article Publish Status: FREE
Abstract Title:

Anti-inflammatory and antioxidant activity of ursolic acid: a systematic review and meta-analysis.

Abstract Source:

Front Pharmacol. 2023 ;14:1256946. Epub 2023 Sep 28. PMID: 37841938

Abstract Author(s):

Man Zhao, Fengyang Wu, Zhaohong Tang, Xinyu Yang, Yanhua Liu, Fengxia Wang, Baojiang Chen

Article Affiliation:

Man Zhao


There is currently evidence suggesting that ursolic acid may exert a favorable influence on both anti-inflammatory and antioxidant impact. Nevertheless, the anti-inflammatory and antioxidant activities of ursolic acid have not been systematically evaluated. Consequently, this study aims to conduct a systematic review and meta-analysis regarding the impact of ursolic acid on markers of inflammatory and antioxidant activity in both animal models andsystems.The search encompassed databases such as PubMed, Web of Science, Google Scholar, and ScienceDirect, up until May 2023. All eligible articles in English were included in the analysis. Standard mean difference (SMD) was pooled using a random-effects model, and the included studies underwent a thorough assessment for potential bias.The final review comprised 31 articles. In disease-model related studies, animal experiments have consistently shown that ursolic acid significantly reduced the levels of inflammatory parameters IL-1β, IL-6 and TNF-αin mouse tissues. In vitro studies have similarly showed that ursolic acid significantly reduced the levels of inflammatory parameters IL-1β, IL-6, IL-8 and TNF-α. Our results showed that ursolic acid could significantly elevate SOD and GSH levels, while significantly reducing MDA levels in animal tissues. The results ofstudies shown that ursolic acid significantly increased the level of GSH and decreased the level of MDA.Findings from both animal andstudies suggest that ursolic acid decreases inflammatory cytokine levels, elevates antioxidant enzyme levels, and reduces oxidative stress levels (graphical abstract). This meta-analysis furnishes compelling evidence for the anti-inflammatory and antioxidant properties of ursolic acid.

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