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Article Publish Status: FREE
Abstract Title:

Anti-inflammatory effect ofseed oil rich in omega-3 fatty acid on dextran sodium sulfate-induced colitis in mice.

Abstract Source:

Res Pharm Sci. 2021 Oct ;16(5):464-473. Epub 2021 Aug 19. PMID: 34522194

Abstract Author(s):

Napapan Kangwan, Komsak Pintha, Chakkrit Khanaree, Sarawut Kongkarnka, Teera Chewonarin, Maitree Suttajit

Article Affiliation:

Napapan Kangwan

Abstract:

Background and purpose: Ulcerative colitis is a chronic inflammatory bowel disease that involves diffused inflammation of the large intestine. Omega-3 fatty acid (FA) has been known to regulate the inflammatory response associated with ulcerative colitis pathogenesis.is a valuable source of omega-3 FA andα-linolenic acid (ALA) contained in its seed oil. Therefore, the aim of this study was to evaluate the anti-inflammatory effect ofseed oil (PSO) on colitis induced by dextran sulfate sodium (DSS) in a mouse model.

Experimental approach: PSO was extracted using a cold-pressed extractor and FA composition of PSO was analyzed by GC-MS. Acute colitis in mice was induced with 3% DSS in drinking water for 7 days. Some mice were treated with PSO (20, 100, 200 mg/kg BW) for 3 weeks before the DSS administration. Sulfasalazine was used as a positive control. The clinical features, histopathologic, serum, and gene expression of proinflammatory cytokines in the colon were assessed.

Finding/Results: PSO contained the highest proportion of ALA (61.51%). Furthermore, PSO pretreatment evidently reduced body weight loss, diminished diarrhea, gross bleeding, and DSS-induced colon shortening. PSO pretreatment attenuated histopathological changes in response to DSS-induced colitis. PSO pretreatment also markedly decreased inflammatory response in serum and the colon tissue of DSS-induced mice.

Conclusion and implication: ALA in PSO is suggested to be mainly responsible for the reduction of DSS-induced colitis through suppressing inflammatory markers. PSO could be further developed as a functional health supplement, which would be beneficial for anti-inflammation in the colonic mucosa.

Study Type : Animal Study

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