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Abstract Title:

Anti-inflammatory labdane diterpenoids from Leonurus japonicus Houtt.

Abstract Source:

Phytochemistry. 2020 May ;173:112223. Epub 2020 Feb 26. PMID: 32113063

Abstract Author(s):

Biao Yang, Yumei Hu, Ningbo Cheng, Zhenzhen Su, Yan Zhong, Zeyu Cao, Liang Cao, Wenzhe Huang, Zhenzhong Wang, Wei Xiao

Article Affiliation:

Biao Yang

Abstract:

Seven undescribed labdane diterpenoids, japonicones A-G, were isolated from the aerial parts of Leonurus japonicus Houtt. Japonicones C-G contained two keto carbonyl groups in their structures attached to C-3 and C-7, which are rare for labdane diterpenoids. The structures and absolute configurations of japonicones A-G were established by means of spectroscopic analyses (HRESIMS, 1D and 2D NMR, and ECD). Their anti-inflammatory activities were evaluated by measuring their inhibitory effects on PGEproduction in LPS-stimulated RAW264.7 macrophages. Japonicones A-D and G showed inhibition of PGEproduction with ICvalues in the range of 8.62-30.71 μM (the positive control paracetamol showed an IC = 5.79 μM).

Study Type : In Vitro Study

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