Anti-influenza activity of a Bacillus subtilis probiotic strain. - GreenMedInfo Summary
Anti-influenza Activity of a Bacillus subtilis Probiotic Strain.
Antimicrob Agents Chemother. 2017 07 ;61(7). Epub 2017 Jun 27. PMID: 28416546
Amongbacteria,is the species that produces the most antimicrobial compounds. In this study, we analyzed the activity of probiotic strain3 against the influenza virus. The antiviral effect of this strain has been demonstratedandA new peptide, P18, produced by the probiotic strain was isolated, purified, chemically synthesized, and characterized. Cytotoxicity studies demonstrated no toxic effect of P18 on Madin-Darby canine kidney (MDCK) cells, even at the highest concentration tested (100μg/ml). Complete inhibition of the influenza viruswas observed at concentrations of 12.5 to 100μg/ml. The protective effect of P18 in mice was comparable to that of oseltamivir phosphate (Tamiflu). Further study will assess the potential of peptide P18 as an antiviral compound and as a promising candidate for the development of new antiviral vaccines.