Article Publish Status: FREE
Abstract Title:

Anti-Influenza with Green Tea Catechins: A Systematic Review and Meta-Analysis.

Abstract Source:

Molecules. 2021 Jun 30 ;26(13). Epub 2021 Jun 30. PMID: 34209247

Abstract Author(s):

Anchalee Rawangkan, Kirati Kengkla, Sukrit Kanchanasurakit, Acharaporn Duangjai, Surasak Saokaew

Article Affiliation:

Anchalee Rawangkan


Influenza is one of the most serious respiratory viral infections worldwide. Although several studies have reported that green tea catechins (GTCs) might prevent influenza virus infection, this remains controversial. We performed a systematic review and meta-analysis of eight studies with 5,048 participants that examined the effect of GTC administration on influenza prevention. In a random-effects meta-analysis of five RCTs, 884 participants treated with GTCs showed statistically significant effects on the prevention of influenza infection compared to the control group (risk ratio (RR) 0.67, 95%CIs 0.51-0.89,= 0.005) without evidence of heterogeneity (= 0%,= 0.629). Similarly, in three cohort studies with 2,223 participants treated with GTCs, there were also statistically significant effects (RR 0.52, 95%CIs 0.35-0.77,= 0.001) with very low evidence of heterogeneity (= 3%,= 0.358). Additionally, the overall effect in the subgroup analysis of gargling and orally ingested items (taking capsules and drinking) showed a pooled RR of 0.62 (95% CIs 0.49-0.77,= 0.003) without heterogeneity (= 0%,= 0.554). There were no obvious publication biases (Egger's test (= 0.138) and Begg's test (= 0.103)). Our analysis suggests that green tea consumption is effective in the prophylaxis of influenza infections. To confirm the findings before implementation, longitudinal clinical trials with specific doses of green tea consumption are warranted.

Study Type : Meta Analysis, Review
Additional Links
Pharmacological Actions : Antiviral Agents : CK(1957) : AC(1034)

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