Abstract Title:

Anti-invasive activity of anthocyanins isolated from Vitis coignetiae in human hepatocarcinoma cells.

Abstract Source:

J Med Food. 2009 Oct ;12(5):967-72. PMID: 19857058

Abstract Author(s):

Dong Yeok Shin, Won Sup Lee, Seok Hyun Kim, Min Jeong Kim, Jeong Won Yun, Jing Nan Lu, Sung Joong Lee, Irina Tsoy, Hye Jung Kim, Chung Ho Ryu, Gi Young Kim, Ho Sung Kang, Sung Chul Shin, Yung Hyun Choi

Article Affiliation:

Dong Yeok Shin


We investigated anti-invasive effects of the anthocyanins from fruits of Vitis coignetiae Pulliat (known as meoru in Korea) on human hepatoma Hep3B cells. The anthocyanins inhibited cell invasion in a dose-dependent manner as measured by Matrigel (BD Biosciences, San Jose, CA, USA) invasion assays. They also inhibited expression of matrix metalloproteinase (MMP)-2 and MMP-9 and activation of nuclear factor kappaB (NF-kappaB) stimulated by tumor necrosis factor alpha. Taken together, the results of this study indicate that the anthocyanins isolated from fruits of V. coignetiae Pulliat have anti-invasive effects on human hepatoma Hep3B cells and inhibit MMP-2 and MMP-9 gene expression at least in part through the inhibition of NF-kappaB activation.

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