Abstract Title:

Anti-proliferative activity of hydnocarpin, a natural lignan, is associated with the suppression of Wnt/β-catenin signaling pathway in colon cancer cells.

Abstract Source:

Bioorg Med Chem Lett. 2013 Oct 15 ;23(20):5511-4. Epub 2013 Aug 22. PMID: 24018191

Abstract Author(s):

Min-Ai Lee, Won Kyung Kim, Hyen Joo Park, Sam Sik Kang, Sang Kook Lee

Article Affiliation:

Min-Ai Lee


Based on the Wnt inhibitors as potential targets in the development of anticancer agents, natural compounds were evaluated forβ-catenin-mediated transcriptional activity. A natural lignan hydnocarpin isolated from Lonicera japonica was considered a potential inhibitor for Wnt/β-catenin signalings. The anti-proliferative activity of hydnocarpin was also found to be associated with the suppression of Wnt/β-catenin-mediated signaling pathway in human colon cancer cells. These data suggest that hydnocarpin might be a novel Wnt inhibitor and has a potential of signaling regulator in β-catenin-mediated signaling pathways.

Study Type : In Vitro Study

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