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Abstract Title:

Anti-tumour potential and selectivity of caffeic acid phenethyl ester in osteosarcoma cells.

Abstract Source:

Tissue Cell. 2021 Nov 27 ;74:101705. Epub 2021 Nov 27. PMID: 34864499

Abstract Author(s):

Ana Lígia Pagnan, Adriano Souza Pessoa, Cintia Kazuko Tokuhara, Vanessa Svizzero Fakhoury, Gabriela Silva Neubern Oliveira, Mariana Liessa Rovis Sanches, Kelly Karina Inacio, Valdecir Farias Ximenes, Rodrigo Cardoso Oliveira

Article Affiliation:

Ana Lígia Pagnan

Abstract:

Osteosarcoma is the most common type of bone cancer, and metastasis is widespread decreasing the survival rate. The search for new therapeutic strategies has increased for phytochemicals due to their potential as antioxidants and anticancer properties. Thus, we evaluated the caffeic acid phenethyl ester (CAPE) and caffeic acid's (CA) anticancer properties on UMR-106 murine osteosarcoma cells. The ICand ICwere 1.3 and 2.7μM for CAPE and 91.0 and 120.0 μM for CA, respectively. This study shows the potential anticancer properties of CAPE and highlights how a phenethyl ester component addition can improve the pharmacological potency in relation to its precursor CA. Our results showed that CAPE was more efficient andselective in reducing the viability of tumor cells compared to the control osteoblasts (MC3T3-E1) (p<0.05). In addition, CAPE was 44-fold (IC) and 70-fold (IC) more cytotoxic than CA. CAPE also decreased ROS generation and cell migration. In summary, CAPE was more selective for tumor cells, preserving normal ones, suggesting its potential role as an anticancer drug.

Study Type : In Vitro Study

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