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Article Publish Status: FREE
Abstract Title:

Antibacterial activity of a berberine nanoformulation.

Abstract Source:

Beilstein J Nanotechnol. 2022 ;13:641-652. Epub 2022 Jul 11. PMID: 35923171

Abstract Author(s):

Hue Thi Nguyen, Tuyet Nhung Pham, Anh-Tuan Le, Nguyen Thanh Thuy, Tran Quang Huy, Thuy Thi Thu Nguyen

Article Affiliation:

Hue Thi Nguyen

Abstract:

This study describes the preparation of berberine (BBR) in nanoformulation to enhance its solubility and increase its antibacterial effectiveness against hospital-acquired infections. BBR nanoparticles (BBR NPs) were formed by antisolvent precipitation (ASP) using glycerol as a safe organic solvent. UV-vis absorption spectra demonstrated that the solubility of BBR NPs was greatly enhanced compared to that of pure BBR. Glycerol played a role as a stabilizer for BBR NPs through the formation of hydrogen bonds between glycerol and BBR NPs. The prepared BBR NPs have a narrow size distribution with an average diameter of 156 nm at a concentration of 2.0 mg/mL, measured by dynamic light scattering. After nanoformulation, the concentration of BBR NPs could reach up to 5.0 mg/mL, which is much higher than the saturation concentration without treatment. Results show a strongly enhanced antibacterial activity of BBR NPs compared with that of pure BBR at the same concentration. The minimum bactericidal concentration of BBR NPs against methicillin-resistantandO157:H7 was found to be 2.0 and 5.0 mg/mL, respectively. Transmission electron microscopy showed that BBR NPs surrounded the bacterial cells and severely damaged the cell walls. Therefore, BBR NPs prepared by ASP appear to be a potential candidate for the treatment of bacterial pathogens.

Study Type : In Vitro Study

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