Article Publish Status: FREE
Abstract Title:

Antidepressant-Like Effect of Selected Egyptian Cultivars of Flaxseed Oil on a Rodent Model of Postpartum Depression.

Abstract Source:

Evid Based Complement Alternat Med. 2017 ;2017:6405789. Epub 2017 Nov 29. PMID: 29333185

Abstract Author(s):

Nebal El Tanbouly, Abeer Mohamed El Sayed, Zeinab Y Ali, Samia Abdel Wahab, Sabah H El Gayed, Shahira M Ezzat, Amira Safwat El Senousy, Mouchira A Choucry, Essam Abdel-Sattar

Article Affiliation:

Nebal El Tanbouly


Flaxseed (L.) is a multipurpose crop with health promoting potential. This study was undertaken to investigate the fatty acid profile and yield of fixed oil of six Egyptian flaxseed cultivars. The selected cultivars with the highest content of polyunsaturated fatty acids (PUFAs) (G9 and G10) were assessed for their antidepressant-like effect in rat model of postpartum depression (PPD) induced by hormone-simulated pregnancy followed by hormone withdrawal and compared to fluoxetine. As compared to control group, administration of G9 and G10 (270 mg/kg/day, p.o) for two weeks during the postpartum period can alleviate anxiety and depressive-like behaviors and biochemical changes in PPD-induced rats. This was confirmed by evaluation of anxiety-like behaviors (elevated plus maze, open field test, and forced swim test tests), in addition tobiochemical analysis (brain monoamine oxidase-A, corticosterone level, proinflammatory cytokines, and hippocampal redox state). In conclusion, flaxseed oil of Egyptian cultivars G9 and G10 exhibited significant antidepressant-like effect in rat model of PPD without affecting locomotor activity. At the treatment doses, the antidepressant-like activity of Giza 9 oil is comparable to fluoxetine.

Study Type : Animal Study

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