Abstract Title:

Piperine from the fruits of Piper longum with inhibitory effect on monoamine oxidase and antidepressant-like activity.

Abstract Source:

Chem Pharm Bull (Tokyo). 2005 Jul;53(7):832-5. PMID: 15997146

Abstract Author(s):

Seon A Lee, Seong Su Hong, Xiang Hua Han, Ji Sang Hwang, Gab Jin Oh, Kyong Soon Lee, Myung Koo Lee, Bang Yeon Hwang, Jai Seup Ro

Article Affiliation:

College of Pharmacy, Chungbuk National University, Cheongju, Korea.


A bioassay-guided isolation of the ethanol extract from the fruits of Piper longum yielded a known piperidine alkaloid, piperine, as a monoamine oxidase (MAO) inhibitor. Piperine showed an inhibitory effect against MAO-A (IC50 value: 20.9 microM) and MAO-B (IC50 value: 7.0 microM). Kinetic analyses by a Lineweaver-Burk plot clearly indicated that piperine competitively inhibited MAO-A and MAO-B with Ki values of 19.0+/-0.9 microM and 3.19+/-0.5 microM, respectively. The inhibition by piperine was found to be reversible by dialysis of the incubation mixture. In addition, the immobility times in the tail suspension test were significantly reduced by piperine, similar to that of the reference antidepressant fluoxetine, without accompanying changes in ambulation when assessed in an open-field. These results suggest that piperine possesses potent antidepressant-like properties that are mediated in part through the inhibition of MAO activity, and therefore represent a promising pharmacotherapeutic candidate as an antidepressant agent.

Study Type : Animal Study

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