Article Publish Status: FREE
Abstract Title:

The antidiabetic effect of thymoquinone: A systematic review and meta-analysis of animal studies.

Abstract Source:

Food Res Int. 2020 Jan ;127:108736. Epub 2019 Oct 15. PMID: 31882078

Abstract Author(s):

Mohammed Bule, Shekoufeh Nikfar, Mohsen Amini, Mohammad Abdollahi

Article Affiliation:

Mohammed Bule


Thymoquinone (2-isopropyl-5-methylbenzo-1, 4-quinone) (TQ) is a quinone derivative with a yellow crystalline appearance, abundantly found in black cumin, Nigella sativa L. TQ has diverse pharmacological properties. The aim of this systematic review on the antidiabetic effects of TQ is to evaluate the currently available evidence and conduct meta-analysis. A literature search of articles published until 25 January 2019 was done on PubMed, EMBASE, Web of Sciences and Scopus databases, using relevant keywords. The meta-analysis included 18 studies that examined the serum glucose (SG) level or serum insulin level or body weight (BW). In the meta-analysis it was found that with an overall pooled standardized mean difference (SMD) of -9.176 mg/dl (95%CI: -10.759, -7.593; p = 0.000); TQ reduced the SG level (-9.176 mg/dl) significantly in the STZ-induced diabetes model. Moreover, a meta-analysis of the effect of TQ on BW demonstrated that TQ has a statistically significant effect on the BW of diabetic animals with an overall pooled SMD of 4.509 (95%CI: 3.234, 5.784; p = 0.000). In addition, the overall pooled estimate of the level of serum insulin was significant with SMD of 1.681 (95%CI: 0.858, 2.503; p = 0.000). Therefore, the meta-analysis showed that TQ has a significant antidiabetic effect through its actionon the SG, serum insulin level, and BW of the animals.

Study Type : Meta Analysis, Review

Print Options

Key Research Topics

Sayer Ji
Founder of GreenMedInfo.com

Subscribe to our informative Newsletter & get Nature's Evidence-Based Pharmacy

Our newsletter serves 500,000 with essential news, research & healthy tips, daily.

Download Now

500+ pages of Natural Medicine Alternatives and Information.

This website is for information purposes only. By providing the information contained herein we are not diagnosing, treating, curing, mitigating, or preventing any type of disease or medical condition. Before beginning any type of natural, integrative or conventional treatment regimen, it is advisable to seek the advice of a licensed healthcare professional.

© Copyright 2008-2022 GreenMedInfo.com, Journal Articles copyright of original owners, MeSH copyright NLM.