Article Publish Status: FREE
Abstract Title:

Antifungal Activity ofMetabolites against Sorghum Pathogens.

Abstract Source:

Plants (Basel). 2019 Mar 22 ;8(3). Epub 2019 Mar 22. PMID: 30909408

Abstract Author(s):

Rajini Sollepura Boregowda, Nandhini Murali, Arakere C Udayashankar, Siddapura R Niranjana, Ole S Lund, Harischandra S Prakash

Article Affiliation:

Rajini Sollepura Boregowda


Unscientific use of synthetic fungicides in plant disease management has environmental ramifications, such as disease resurgence and serious health problems due to their carcinogenicity. This has prompted the identification and development of eco-friendly greener alternatives.extract was evaluated for its antifungal activity in in vitro and in vivo against sorghum fungal pathogensand. The column purified methanolic extract ofexhibited good antifungal activity against the target pathogens. The MIC was observed at 80 mg/mL for all tested pathogenic fungi, whereas MFC was 80 mg/mL for, 100 mg/mL for,andIn vitro germination percentage was significantly high in seeds treated withextract (98%) over untreated control (91%). Significant disease protection of 95% was observed in greenhouse and 66% disease protection was noticed in field experiments. The efficacy ofextract in field conditions was improved with the use ofextract formulation. The profile of phytochemicals inmethanol fractions was obtained by ultra-performance liquid chromatography (UPLC) mass spectroscopy. The [M-H]at/313.3,/797.9, and/269.0 revealed the presence of wedelolactone, eclalbasaponin II, and apigenin, respectively. The H-nuclear magnetic resonance spectroscopy (¹H-NMR) chemical shift value supported the findings of the mass spectrometry. The results highlighted the possible use ofmethanolic extract as alternative to chemical fungicide in sorghum disease management.

Study Type : In Vitro Study
Additional Links
Pharmacological Actions : Antifungal Agents : CK(494) : AC(306)

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