Antifungal Properties ofL. Supercritical Fluid Extract Againstand.
Molecules. 2019 Sep 28 ;24(19). Epub 2019 Sep 28. PMID: 31569357
In this study, potential antifungal properties of a brown algawere evaluated. The algal extract was obtained with the use of supercritical fluid extraction (scCO) at a temperature of 50°C under a pressure of 300 bar. The aqueous solution of the extract at the concentration of 0.05%, 0.2%, 0.5% and 1.0% was studied against pathogenic fungi on a liquid RB medium. This study is the first report on antifungal properties of the brown algaescCOextract againstandphytopathogens. The concentrations of the studied extract (0.5% and 1.0%) were demonstrated to have an ability to inhibit 100% growth of macroconidia within 144 h, as well as an ability to cause their total degradation. As a result of the study, the antifungal effect of fucosterol againstwas also indicated. The total macroconidia growth was inhibited by 1.0% fucosterol. Moreover, at lower concentrations (0.05-0.2%) of fucosterol, macroconidia were characterized by shorter length and structural degradation was observed. The mycelial growth of(Fo38) by 1% scCOextract was analyzed at the level of 48% after 168 h of incubation, whereas 100% extract was found to be effective in(CBS122) and(Fo38) growth inhibition by 72% and 75%, respectively after 168 h of incubation.