Antihyperglycemic and Antihyperlipidemic effects of Lippia citriodora. - GreenMedInfo Summary
Antihyperglycemic and Antihyperlipidemic Effects of Lippia citriodora in Rats.
Endocr Metab Immune Disord Drug Targets. 2021 ;21(4):711-719. PMID: 32520695
Fadwa El-Ouady
AIM: The study was conducted to assess the antidiabetic and antihyperlipidemic effects of Lippia citriodora.
BACKGROUND: Lippia citriodora Kunth (Verbenaceae) is a medicinal plant with many traditional uses.
OBJECTIVE: The goal of this study was to investigate the antidiabetic activity of aqueous extract of Lippia citriodora and its capacity to improve the lipid profile in diabetic rats.
METHODS: Normal and diabetic rats were treated orally for 15 days by the leaves aqueous extract of Lippia citriodora (LCLAE) (100 mg/kg). The whole glucose utilization and liver architecture were also evaluated. The in vitro antioxidant activity of LCLAE was also assessed.
RESULTS: LCLAE lowered blood glucose and lipid levels in all groups. Moreover, LCLAE ameliorated the liver structure and exhibited antioxidant activity.
CONCLUSION: In conclusion, this study demonstrates the hypoglycemic and antihyperlipidemic effects of LCLAE in rats.