Abstract Title:

Antileishmanial Germacranolides from Calea zacatechichi.

Abstract Source:

Planta Med. 2011 May ;77(7):749-53. Epub 2010 Dec 2. PMID: 21128202

Abstract Author(s):

Hankui Wu, Frank R Fronczek, Charles L Burandt, Jordan K Zjawiony

Article Affiliation:

Hankui Wu


Phytochemical study of the leaves and stems of Calea zacatechichi Schl. (Asteraceae) led to the isolation of a series of six germacranolides (1-6) with significant antileishmanial activity. The structure of a new compound named by us as calealactone D (1) was determined by NMR and MS, and its absolute configuration by X-ray crystallography. In addition, calealactone E (5) was discovered as a new naturally occurring compound, and the absolute configuration of calealactone C (2) was also determined by X-ray crystallography. All compounds were biologically evaluated in antimicrobial and antiprotozoal assays.

Study Type : In Vitro Study

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