n/a
Article Publish Status: FREE
Abstract Title:

Antimetastatic Effects of Curcumin in Oral and Gastrointestinal Cancers.

Abstract Source:

Front Pharmacol. 2021 ;12:668567. Epub 2021 Aug 11. PMID: 34456716

Abstract Author(s):

Amirhossein Davoodvandi, Marjan Farshadi, Noushid Zare, Seyed Amirreza Akhlagh, Esmail Alipour Nosrani, Maryam Mahjoubin-Tehran, Parisa Kangari, Seyedeh Maryam Sharafi, Haroon Khan, Michael Aschner, Ghazaleh Baniebrahimi, Hamed Mirzaei

Article Affiliation:

Amirhossein Davoodvandi

Abstract:

Gastrointestinal (GI) cancers are known as frequently occurred solid malignant tumors that can cause the high rate mortality in the world. Metastasis is a significant destructive feature of tumoral cells, which directly correlates with decreased prognosis and survival. Curcumin, which is found in turmeric, has been identified as a potent therapeutic natural bioactive compound (Curcuma longa). It has been traditionally applied for centuries to treat different diseases, and it has shown efficacy for its anticancer properties. Numerous studies have revealed that curcumin inhibits migration and metastasis of GI cancer cells by modulating various genes and proteins, i.e., growth factors, inflammatory cytokines and their receptors, different types of enzymes, caspases, cell adhesion molecules, and cell cycle proteins. Herein, we summarized the antimetastatic effects of curcumin in GI cancers, including pancreatic cancer, gastric cancer, colorectal cancer, oral cancer, and esophageal cancer.

Study Type : Review

Print Options


Key Research Topics

Sayer Ji
Founder of GreenMedInfo.com

Subscribe to our informative Newsletter & get Nature's Evidence-Based Pharmacy

Our newsletter serves 500,000 with essential news, research & healthy tips, daily.

Download Now

500+ pages of Natural Medicine Alternatives and Information.

This website is for information purposes only. By providing the information contained herein we are not diagnosing, treating, curing, mitigating, or preventing any type of disease or medical condition. Before beginning any type of natural, integrative or conventional treatment regimen, it is advisable to seek the advice of a licensed healthcare professional.

© Copyright 2008-2021 GreenMedInfo.com, Journal Articles copyright of original owners, MeSH copyright NLM.