Antimicrobial activity ofextracts against multi-drug resistantfrom patients of urinary tract infection.
Pak J Med Sci. 2018 May-Jun;34(3):616-620. PMID: 30034426
Background and Objective: is the most common etiological agent of UTI and accounts for more then 100, 0000 hospitalization annually. The objective of this study was to investigate the antimicrobial activity of aqueous and ethanolic extracts ofagainstfrom urinary tract infection patients.
Methods: Urine samples of forty four suspected patients from Tertiary Care Hospital Faisalabad were used in this study. Ethanolic and aqueous extracts of(PV), a medicinal plant was evaluated for its ability to inhibit the growth of 38 resistant isolates ofstrains and compared to Ciprofloxacin, Ofloxacin, Cefixime and Tobramycin by well diffusion method. Minimum inhibitory concentration was measured by using broth micro dilution method.
Results: PV showed antibacterial activity againststrains, however Tobramycin at 10 microgram (10μg) inhibited the resistantto a greater extent as compared to other antibiotics and was resistant to twice less number of strains, about 82% ofisolates have MDR pattern.
Conclusion: Ciprofloxacin has more efficacy than PV and no synergistic effect with extracts of PV. Cefixime is least efficacious against resistant, however it has synergistic effect with extracts of PV.