Article Publish Status: FREE
Abstract Title:

Antioxidant and antinociceptive effects of Citrus limon essential oil in mice.

Abstract Source:

J Biomed Biotechnol. 2011 ;2011:678673. Epub 2011 May 31. PMID: 21660140

Abstract Author(s):

Lidianne Mayra Lopes Campêlo, Antonia Amanda C de Almeida, Rizângela L Mendes de Freitas, Gilberto Santos Cerqueira, Geane Felix de Sousa, Gláucio Barros Saldanha, Chistiane Mendes Feitosa, Rivelilson Mendes de Freitas

Article Affiliation:

Lidianne Mayra Lopes Campêlo


The antioxidant and antinociceptive activities of Citrus limon essential oil (EO) were assessed in mice or in vitro tests. EO possesses a strong antioxidant potential according to the scavenging assays. Moreover, it presented scavenger activity against all in vitro tests. Orally, EO (50, 100, and 150  mg/kg) significantly reduced the number of writhes, and, at highest doses, it reduced the number of paw licks. Whereas naloxone antagonized the antinociceptive action of EO (highest doses), this suggested, at least, the participation of the opioid system. Further studies currently in progress will enable us to understand the action mechanisms of EO.

Study Type : Animal Study

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