Antioxidant and lipid-reducing effects of Rosa rugosa root extract in 3T3-L1 cell. - GreenMedInfo Summary
Antioxidant and lipid-reducing effects ofroot extract in 3T3-L1 cell.
Food Sci Biotechnol. 2022 Jan ;31(1):121-129. Epub 2021 Dec 18. PMID: 35059236
Da-Hye Choi
root is traditionally known to be effective in the treatment of diabetes in Korea.root-specific compounds also show antioxidant effects, and could reduce lipid and fat accumulation, however, the underlying mechanism has not been clarified. In present study, the antioxidant and lipid-reducing effects of a 50% ethanol extract of(REE) were investigated differentiated mouse preadipocytes (3T3-L1 cells). REE showed strong radical scavenging activities and inhibitory effect of total lipid accumulation and triglyceride levels in differentiated 3T3-L1 cells. In addition, REE treatment reduced the mRNA and protein levels of adipogenesis and lipogenesis markers. This REE-promoted lipid reduction was caused by downregulation of peroxisome proliferator activated receptor gamma (), CCAAT/enhancer binding protein alpha (), and sterol regulatory element binding protein1 () and down regulation of ERK expression. Overall, these results demonstrate the potential of REE for development of a drug in the medical treatment of lipid-associated disorders.