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Abstract Title:

Antioxidant and lipid-reducing effects ofroot extract in 3T3-L1 cell.

Abstract Source:

Food Sci Biotechnol. 2022 Jan ;31(1):121-129. Epub 2021 Dec 18. PMID: 35059236

Abstract Author(s):

Da-Hye Choi, Joon-Hee Han, Min Hong, Sun-Yeop Lee, Soo-Ung Lee, Tae-Hyung Kwon

Article Affiliation:

Da-Hye Choi

Abstract:

root is traditionally known to be effective in the treatment of diabetes in Korea.root-specific compounds also show antioxidant effects, and could reduce lipid and fat accumulation, however, the underlying mechanism has not been clarified. In present study, the antioxidant and lipid-reducing effects of a 50% ethanol extract of(REE) were investigated differentiated mouse preadipocytes (3T3-L1 cells). REE showed strong radical scavenging activities and inhibitory effect of total lipid accumulation and triglyceride levels in differentiated 3T3-L1 cells. In addition, REE treatment reduced the mRNA and protein levels of adipogenesis and lipogenesis markers. This REE-promoted lipid reduction was caused by downregulation of peroxisome proliferator activated receptor gamma (), CCAAT/enhancer binding protein alpha (), and sterol regulatory element binding protein1 () and down regulation of ERK expression. Overall, these results demonstrate the potential of REE for development of a drug in the medical treatment of lipid-associated disorders.

Study Type : In Vitro Study

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