Article Publish Status: FREE
Abstract Title:

Melatonin Regulates Oxidative Stress Initiated by Freund's Complete Adjuvant.

Abstract Source:

Acta Medica (Hradec Kralove). 2015 ;58(1):21-4. PMID: 26454803

Abstract Author(s):

Miroslav Pohanka, Branislav Ruttkay-Nedecký, Josef Fusek, Vojtěch Adam, René Kizek

Article Affiliation:

Miroslav Pohanka


Melatonin is a hormone with strong antioxidant properties. In this experiment, Freund's complete adjuvant was used as a stressogenic substance given to laboratory outbred mice, whereas melatonin was investigated as a protectant against the stressogenic effect. Levels of low molecular weight antioxidants, thiobarbituric acid reactive substances, and tumor necrosis factorα and activity of glutathione reductase were determined in blood from the animals. Surprisingly, melatonin was not involved in direct regulation of antioxidants, thiobarbituric acid reactive substances and tumor necrosis factor α. On the other hand, melatonin regulated glutathione reductase activity. We can conclude on regulation of metabolism caused by melatonin in the model. The effect was more important than the expected regulation of immunity and basal oxidative homeostasis.

Study Type : Animal Study

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