Antioxidant efficacy of a spirulina liquid extract on oxidative stress status and metabolic disturbances in subjects with metabolic syndrome. - GreenMedInfo Summary

Lipid peroxidation is associated with the development of some pathologies, such as cardiovascular diseases. Reduction in oxidative stress by antioxidants, such as(formely), helps improving this redox imbalance. The aim of the study was to evaluate the effect of theliquid extract "Spirulysat" on oxidative markers-in particular, oxidized LDL (oxLDL)/total LDL cholesterol-and isoprostanes and to investigate its impact on lipid and glucose metabolism in the metabolic syndrome subject. A controlled, randomised, double-blind design was conducted in 40 subjects aged 18 to 65 years with metabolic syndrome after a daily intake of Spirulysator placebo for twelve weeks. Blood and urinary samples were collected at three visits (V1, V2, V3) in the two groups for parameters determination. Although the Spirulysatgroup showed a decrease at all visits of the oxLDL/total cholesterol ratio, there was no significant difference compared to the placebo (= 0.36). The urinary isoprostanes concentration in the Spirulysatgroup was reduced (= 0.014) at V3. Plasma triglycerides decreased at V3 (= 0.003) and HDL-cholesterol increased (= 0.031) at all visits with Spirulysat. In conclusion, Spirulysatdid not change the oxidized LDL (oxLDL)/LDL ratio but decreased the urinary isoprostanes, plasma triglycerides and increased HDL cholesterol, suggesting a beneficial effect on metabolic syndrome.