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Abstract Title:

Antioxidant-RichLeaf Extract Alleviates Depressive-Like Behaviors and Impede Hyperglycemia.

Abstract Source:

Plants (Basel). 2021 Feb 3 ;10(2). Epub 2021 Feb 3. PMID: 33546288

Abstract Author(s):

Mohammed Abu Tayab, Kazi Ashfak Ahmed Chowdhury, Md Jabed, Syed Mohammed Tareq, A T M Mostafa Kamal, Mohammad Nazmul Islam, A M Kafil Uddin, Mohammad Adil Hossain, Talha Bin Emran, Jesus Simal-Gandara

Article Affiliation:

Mohammed Abu Tayab

Abstract:

Dhaiphul () is a frequently demanded plant in South-East Asian regions for its diverse medicinal values. This study was proposed to examine antioxidant, antidiabetic, and antidepressant potentials of methanol extract ofleaves (MEWF) and its derived n-hexane (NHFMEWF) and ethyl acetate (EAFMEWF) fractions through in vitro, in vivo, and computational models. Among test samples, MEWF and EAFMEWF contained the highest phenolic content and showed maximal antioxidant activity in DPPH radical scavenging and ferric reducing power assays. In comparison, NHFMEWF possessed maximum flavonoid content and a significantly potentα-amylase inhibitory profile comparable with positive control acarbose. In animal models of depression (forced swimming and tail suspension test), EAFMEWF and NHFMEWF demonstrated a dose-dependent antidepressant-like effect; explicitly, the depressive-like behaviors significantly declined in EAFMEWF-treated dosing groups in contrast to the control group. In the computational analysis, previously isolated flavonoid compounds from Dhaiphul leaves manifested potent binding affinity against several key therapeutic target proteins of diabetes and depressive disorders including α-amylase, serotonin transporter, dopamine transporter, and neuronal nitric oxide synthase with varying pharmacokinetics and toxicity profiles. This research's outcomes may provide potential dietary supplements for mitigating hyperglycemia, cellular toxicity, and depressive disorder.

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