Antiproliferative activity on human colon adenocarcinoma cells and antioxidant effect of anthocyanin-rich extracts from peels of species of the Myrtaceae family. - GreenMedInfo Summary

There is a significant indication of the beneficial health effects of fruit rich diets. Fruits of native plant species have noticeably different phytochemicals and bioactive effects. The aim of this work was to characterize and compare the constituents of jabuticaba (, MJ), jamun-berry (, SC), and malay-apple (, SM) extracts and their influence on antioxidant activity in vitro and antiproliferative effects on human colon adenocarcinoma cells. According to the results, dried peel powders (DP) have a high anthocyanin content, phenolic compounds, and antioxidant activity when compared to freeze dried extracts (FD).dried peel powder extract had a higher total anthocyanin and phenolic compounds content (802.90± 1.93 and 2152.92 ± 43.95 mg/100 g, respectively). A reduction in cell viability of HT-29 cells after treatment withextracts (DP-MJ and FD-MJ) was observed via MTT assay. Flow cytometry showed that the treatment with the anthocyanin-rich extracts from MJ, SC, and SM had an inhibitory impact on cell development due to G/M arrest and caused a rise in apoptotic cells in relation to the control group. The findings of this study highlight the potential of peel powders fromfruits as an important source of natural antioxidants and a protective effect against colon adenocarcinoma.