Abstract Title:

Antiproliferative Flavanoid Dimers Isolated from Brazilian Red Propolis.

Abstract Source:

J Nat Prod. 2020 06 26 ;83(6):1784-1793. Epub 2020 Jun 11. PMID: 32525315

Abstract Author(s):

Thais P Banzato, Juliana R Gubiani, Darlon I Bernardi, Cláudio R Nogueira, Afif F Monteiro, Fernanda F Juliano, Severino M de Alencar, Ronaldo A Pilli, Carolina A de Lima, Giovanna B Longato, Antonio G Ferreira, Mary Ann Foglio, João E de Carvalho, Débora B Vendramini-Costa, Roberto G S Berlinck

Article Affiliation:

Thais P Banzato


Herein reported are results of the chemical and biological investigation of red propolis collected at the Brazilian Northeast coastline. New propolones A-D (-), with a 3-{3-[(2-phenylbenzofuran-3-yl)methyl]phenyl}chromane skeleton; propolonones A-C (-), with a 3-[3-(3-benzylbenzofuran-2-yl)phenyl]chromane skeleton; and propolol A (), with a 6-(3-benzylbenzofuran-2-yl)-3-phenylchromane skeleton, were isolated as constituents of Brazilian red propolis by cytotoxicity-guided assays and structurally identified by analysis of their spectroscopic data. Propolone B () and propolonone A () display significant cytotoxic activities against an ovarian cancer cell line expressing a multiple drug resistance phenotype when compared with doxorubicin.

Study Type : In Vitro Study

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