n/a
Abstract Title:

Antiproliferative Flavanoid Dimers Isolated from Brazilian Red Propolis.

Abstract Source:

J Nat Prod. 2020 06 26 ;83(6):1784-1793. Epub 2020 Jun 11. PMID: 32525315

Abstract Author(s):

Thais P Banzato, Juliana R Gubiani, Darlon I Bernardi, Cláudio R Nogueira, Afif F Monteiro, Fernanda F Juliano, Severino M de Alencar, Ronaldo A Pilli, Carolina A de Lima, Giovanna B Longato, Antonio G Ferreira, Mary Ann Foglio, João E de Carvalho, Débora B Vendramini-Costa, Roberto G S Berlinck

Article Affiliation:

Thais P Banzato

Abstract:

Herein reported are results of the chemical and biological investigation of red propolis collected at the Brazilian Northeast coastline. New propolones A-D (-), with a 3-{3-[(2-phenylbenzofuran-3-yl)methyl]phenyl}chromane skeleton; propolonones A-C (-), with a 3-[3-(3-benzylbenzofuran-2-yl)phenyl]chromane skeleton; and propolol A (), with a 6-(3-benzylbenzofuran-2-yl)-3-phenylchromane skeleton, were isolated as constituents of Brazilian red propolis by cytotoxicity-guided assays and structurally identified by analysis of their spectroscopic data. Propolone B () and propolonone A () display significant cytotoxic activities against an ovarian cancer cell line expressing a multiple drug resistance phenotype when compared with doxorubicin.

Study Type : In Vitro Study

Print Options


Key Research Topics

Sayer Ji
Founder of GreenMedInfo.com

Subscribe to our informative Newsletter & get Nature's Evidence-Based Pharmacy

Our newsletter serves 500,000 with essential news, research & healthy tips, daily.

Download Now

500+ pages of Natural Medicine Alternatives and Information.

This website is for information purposes only. By providing the information contained herein we are not diagnosing, treating, curing, mitigating, or preventing any type of disease or medical condition. Before beginning any type of natural, integrative or conventional treatment regimen, it is advisable to seek the advice of a licensed healthcare professional.

© Copyright 2008-2021 GreenMedInfo.com, Journal Articles copyright of original owners, MeSH copyright NLM.