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Abstract Title:

Antiprotozoal Isoprenoids from Salvia hydrangea.

Abstract Source:

J Nat Prod. 2018 12 28 ;81(12):2682-2691. Epub 2018 Dec 19. PMID: 30565934

Abstract Author(s):

Marzieh Tabefam, Mahdi Moridi Farimani, Ombeline Danton, Justine Ramseyer, Samad Nejad Ebrahimi, Markus Neuburger, Marcel Kaiser, Peyman Salehi, Olivier Potterat, Matthias Hamburger

Article Affiliation:

Marzieh Tabefam

Abstract:

Fractionation of the n-hexane extract of Salvia hydrangea afforded seven isoprenoids including six new compounds (1-6) and salvadione A (7). Their structures were established by comprehensive spectroscopic and spectrometric data analysis (1D and 2D NMR, HRMS). The absolute configuration of salvadione A (7) was established by single-crystal X-ray diffraction analysis with Cu/Kα radiation. In addition, the absolute configuration of all compounds was determined by electronic circular dichroism spectroscopy. A biosynthetic pathway for the formation of the scaffold of 1 is proposed. The antiprotozoal activity of the compounds against Trypanosoma brucei rhodesiense, Trypanosoma cruzi, Leishmania donovani, and Plasmodium falciparum was determined, and cytotoxicity was assessed in rat myoblast L6 cells. Perovskone C (2) exhibited good activity against P. falciparum (IC0.6μM) and a selectivity index of 62.2.

Study Type : In Vitro Study
Additional Links
Pharmacological Actions : Antiprotozoal Agents : CK(61) : AC(32)

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