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Article Publish Status: FREE
Abstract Title:

Antiviral, Cytotoxic, and Antioxidant Activities of Three Edible Agaricomycetes Mushrooms:,, and.

Abstract Source:

J Fungi (Basel). 2021 Aug 8 ;7(8). Epub 2021 Aug 8. PMID: 34436184

Abstract Author(s):

Shaza M Elhusseiny, Taghrid S El-Mahdy, Mohamed F Awad, Nooran S Elleboudy, Mohamed M S Farag, Khaled M Aboshanab, Mahmoud A Yassien

Article Affiliation:

Shaza M Elhusseiny

Abstract:

In this study, we investigated aqueous extracts of three edible mushrooms:(white button mushroom),(oyster mushroom), and(grey oyster mushroom). The extracts were biochemically characterized for total carbohydrate, phenolic, flavonoid, vitamin, and protein contents besides amino acid analysis. Triple TOF proteome analysis showed 30.1% similarity between proteomes of the twospp. All three extracts showed promising antiviral activities. Whileextract showed potent activity against adenovirus (Ad7, selectivity index (SI) = 4.2),showed strong activity against herpes simplex II (HSV-2; SI = 3.7). The extracts showed low cytotoxicity against normal human peripheral blood mononuclear cells (PBMCs) and moderate cytotoxicity against prostate (PC3, DU-145); colorectal (Colo-205); cecum carcinoma (LS-513); liver carcinoma (HepG2); cervical cancer (HeLa); breast adenocarcinoma (MDA-MB-231 and MCF-7) as well as leukemia (CCRF-CEM); acute monocytic leukemia (THP1); acute promyelocytic leukemia (NB4); and lymphoma (U937) cell lines. Antioxidant activity was evaluated using 2,2-diphenyl-1-picryl-hydrazyl-hydrate (DPPH) radical scavenging, 2,2'-Azinobis-(3-Ethylbenzthiazolin-6-Sulfonic Acid) ABTS radical cation scavenging, and oxygen radical absorbance capacity (ORAC) assays. The three extracts showed potential antioxidant activities with the maximum activity recorded for(ICµg/mL) = 35.13 ± 3.27 for DPPH, 13.97 ± 4.91 for ABTS, and 29.42 ± 3.21 for ORAC assays.

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