Article Publish Status: FREE
Abstract Title:

Antiviral Properties of Baicalin: a Concise Review.

Abstract Source:

Rev Bras Farmacogn. 2021 Oct 6:1-12. Epub 2021 Oct 6. PMID: 34642508

Abstract Author(s):

Kunwei Li, Yiyu Liang, Ao Cheng, Qi Wang, Ying Li, Haocheng Wei, Changzheng Zhou, Xinhuan Wan

Article Affiliation:

Kunwei Li


: Baicalin is one of the bioactive flavonoid glycosides isolated from the dried root ofGeorgi, Lamiaceae, with antiviral properties. In recent years, the antiviral activity of baicalin has been widely investigated to explore its molecular mechanism of action. In this mini-review, the molecular mechanisms of action of baicalin as an antiviral agent are evaluated, which included three categories: the inhibition or stimulation of JAK/STAT, TLRs, and NF-κB pathways; up or down modulation of the expression levels of IFN, IL, SOCS1/3, PKR protein, Mx1 protein, and AP-1 protein; and inhibition of cell apoptosis caused by virus infection. In addition, clinical studies of baicalin are also discussed. This literature search suggested that baicalin can serve as a potential candidate for the development of a novel broad-spectrum antiviral drug.

Supplementary Information: The online version contains supplementary material available at 10.1007/s43450-021-00182-1.

Study Type : Review

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