Abstract Title:

Molecular docking of selected phytocompounds with H1N1 Proteins.

Abstract Source:

Bioinformation. 2015 ;11(4):196-202. Epub 2015 Apr 30. PMID: 26124560

Abstract Author(s):

Mohammed I Alhazmi

Article Affiliation:

Mohammed I Alhazmi


The H1N1 influenza virus is a serious threat to human population. Oseltamivir and Zanamivir are known antiviral drugs for swine flu with observed side effects. These drugs are viral neuraminidase and hemagglutinin inhibitor prevents early virus multiplication by blocking sialic acid cleavage on host cells. Therefore, it is of interest to identify naturally occurring novel compounds to control viral growth. Thus, H1N1 proteins (neuraminidase and hemagglutinin) were screened with phytocompounds isolated from Tulsi plant (Ocimum sanctum L.) using molecular docking tools. This identified Apigenin as an alternative to Oseltamivir and Zanamivir with improved predicted binding properties. Hence, it is of interest to consider this compound for further in vitro and in vivo evaluation.

Study Type : In Vitro Study

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