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Article Publish Status: FREE
Abstract Title:

AnEvaluation of the Antiproliferative and Antiangiogenic Effect of Flavone Apigenin against SK-MEL-24 Human Melanoma Cell Line.

Abstract Source:

Anal Cell Pathol (Amst). 2021 ;2021:5552664. Epub 2021 Jun 21. PMID: 34239802

Abstract Author(s):

Alexandra Ghiƫu, Ioana Zinuca Pavel, Stefana Avram, Brigitta Kis, Daliana Minda, Cristina Adriana Dehelean, Valentina Buda, Roxana Folescu, Corina Danciu

Article Affiliation:

Alexandra Ghiƫu

Abstract:

One of the most important class of natural compounds with successful preclinical results in the management of cancer is the flavonoids. Due to the plethora of biological activities, apigenin (4',5,7 trihydroxyflavone) is a main representant of the flavone subclass. Although the antiproliferative and antiangiogenic effects of apigenin were studied on a significant number of human and murine melanoma cell lines, in order to complete the data existing in the literature, the aim of this study is to evaluate theeffect of apigenin on SK-MEL-24 human melanoma cell line as well ason tumor angiogenesis using the aforementioned cell line on the chorioallantoic membrane assay. Results have shown that in the range of tested doses, the phytocompound presents significant antiproliferative, cytotoxic, and antimigratory potential at 30 M, respectively, 60 M. Moreover, the phytocompound in both tested concentrations limited melanoma cell growth and migration and induced a reduced angiogenic reaction limiting melanoma cell development.

Study Type : Animal Study, In Vitro Study

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