Abstract Title:

Comparative study on the effects of apple peel polyphenols and apple flesh polyphenols on cardiovascular risk factors in mice.

Abstract Source:

Clin Exp Hypertens. 2017 Nov 6:1-8. Epub 2017 Nov 6. PMID: 29106302

Abstract Author(s):

Jia Tian, Xiaoyan Wu, Moyang Zhang, Zhongyi Zhou, Yingfeng Liu

Article Affiliation:

Jia Tian


Apple consumption has been demonstrated to be associated with reduced risk of cardiovascular disease, and the beneficial effect is probably due to the polyphenols in apple. Here, we for the first time evaluated and compared the in vivo effects of the polyphenolic extracts of apple peels (PAP) and apple fleshes (PAF) on blood pressure, vascular endothelial function, lipid metabolism and insulin resistance. A high-fat and high-fructose (HFHF) diet was used to cause cardiovascular disorders in mice, with blood pressure, serum ET-1, TC, TG, LDL-C, glucose and insulin levels increased, and serum NO and HDL-C levels decreased. Mice administered with 250 mg/kg of PAP and PAF for 28 days showed lower blood pressure, improved endothelial function, ameliorated lipid homeostasis and decreased insulin resistance compared with HFHF-fed mice. Furthermore, PAP exhibited much more potent cardioprotective effects than PAF in mice. Quantification and phenolic profile analysis showed that PAP contained remarkably higher amount of total phenolics and total flavonoids than PAF, and this may be the reason for the relatively stronger efficacy of PAP. This study demonstrates that apple polyphenols possess potential cardioprotective effects, and suggests that apple, especially apple peel, may be excellent source for exploration of preventive agents against cardiovascular disorders.

Study Type : Animal Study

Print Options

Key Research Topics

Sayer Ji
Founder of GreenMedInfo.com

Subscribe to our informative Newsletter & get Nature's Evidence-Based Pharmacy

Our newsletter serves 500,000 with essential news, research & healthy tips, daily.

Download Now

500+ pages of Natural Medicine Alternatives and Information.

This website is for information purposes only. By providing the information contained herein we are not diagnosing, treating, curing, mitigating, or preventing any type of disease or medical condition. Before beginning any type of natural, integrative or conventional treatment regimen, it is advisable to seek the advice of a licensed healthcare professional.

© Copyright 2008-2022 GreenMedInfo.com, Journal Articles copyright of original owners, MeSH copyright NLM.