Article Publish Status: FREE
Abstract Title:

The Possible Protective Effect of Apple Cider Vinegar on Mercuric Chloride-Induced Changes on Rat Hepatocytes: Immunohistochemical and Ultrastructure Study.

Abstract Source:

J Microsc Ultrastruct. 2020 Jul-Sep;8(3):126-131. Epub 2020 Sep 10. PMID: 33282688

Abstract Author(s):

Samah Kandeel, Heba H Elkaliny

Article Affiliation:

Samah Kandeel


Introduction: Mercuric chloride is a toxic form of mercury capable for induction of oxidative liver damage. Apple cider vinegar (ACV) is a powerful antioxidant agent being used in salad dressings. Our study aimed to assess the beneficial effect of ACV against mercuric chloride-induced hepatic cell damage through an ultrastructural and immunohistochemical study.

Materials and Methods: Forty Wistar rats used divided into four groups (10 rats each); control; Group A (ACV): Rats received 2 ml/kg ACV; Group B (HgCl): Rats received 1 mg/kg HgCl, and Group C (ACV + HgCl): Rats received 2 ml/kg ACV 30 min before giving 1 mg/kg HgCl. Doses given orally by intragastric tube for 30 days.

Results: Toluidine blue results of HgClgroup revealed hepatocytes with irregular boundaries, eccentric deeply stained nuclei, and large cytoplasmic vacuoles. Electron microscopic results showed dilated rough endoplasmic reticulum, and smooth endoplasmic reticulum, cytoplasmic vacuolations, areas of cytoplasmic rarefaction, degenerated mitochondria, nuclear membrane irregularities, and dilated bile canaliculi with lost microvilli. Moreover, there was significantly increased expression of HSP60 and number of hepatocytes with proliferating cell nuclear antigen-positive nuclei. ACV + HgClgroup showed improvement of the previous changes.

Conclusion: ACV could be promising for attenuation of liver cell damages induced by several toxins through its powerful antioxidant properties.

Study Type : Animal Study

Print Options

Key Research Topics

Sayer Ji
Founder of GreenMedInfo.com

Subscribe to our informative Newsletter & get Nature's Evidence-Based Pharmacy

Our newsletter serves 500,000 with essential news, research & healthy tips, daily.

Download Now

500+ pages of Natural Medicine Alternatives and Information.

This website is for information purposes only. By providing the information contained herein we are not diagnosing, treating, curing, mitigating, or preventing any type of disease or medical condition. Before beginning any type of natural, integrative or conventional treatment regimen, it is advisable to seek the advice of a licensed healthcare professional.

© Copyright 2008-2023 GreenMedInfo.com, Journal Articles copyright of original owners, MeSH copyright NLM.