Abstract Title:

A pilot study to investigate the role of the 26S proteasome in radiotherapy resistance and loco-regional recurrence following breast conserving therapy for early breast cancer.

Abstract Source:

Breast. 2011 Mar 14. Epub 2011 Mar 14. PMID: 21411324

Abstract Author(s):

Dalia Elfadl, Victoria C Hodgkinson, Ervine D Long, Lucy Scaife, Philip J Drew, Michael J Lind, Lynn Cawkwell

Article Affiliation:

Cancer Biology Proteomics Group, Postgraduate Medical Institute of the University of Hull, Hull, UK; Academic Surgical Unit, Hull and East Yorkshire NHS Trust, Hull, UK.


Breast conserving therapy is a currently accepted method for managing patients with early stage breast cancer. However, approximately 7% of patients may develop loco-regional tumour recurrence within 5 years. We previously reported that expression of the 26S proteasome may be associated with radio-resistance. Here we aimed to analyse the 26S proteasome in a pilot series of early breast cancers and correlate the findings with loco-regional recurrence. Fourteen patients with early breast cancer who developed loco-regional recurrence within 4 years of completing breast conserving therapy were selected according to strict criteria and compared with those from 14 patients who were disease-free at 10 years. Decreased expression of the 26S proteasome was significantly associated with radio-resistance, manifested as the development of a loco-regional recurrence within 4 years of breast conserving therapy (p=0.018). This small pilot study provides further suggestion that the 26S proteasome may be associated with response to radiotherapy.

Study Type : Human Study
Additional Links
Anti Therapeutic Actions : Radiotherapy : CK(417) : AC(75)

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