Abstract Title:

An arabinogalactan fromattenuates DSS-induced chronic colitis in C57BL/6J mice associated with the modulation of intestinal barrier function and gut microbiota.

Abstract Source:

Food Funct. 2021 Oct 19 ;12(20):9829-9843. Epub 2021 Oct 19. PMID: 34664587

Abstract Author(s):

Cui Cao, Beiwei Zhu, Zhengqi Liu, Xue Wang, Chunqing Ai, Guiping Gong, Minghua Hu, Linjuan Huang, Shuang Song

Article Affiliation:

Cui Cao


Ulcerative colitis (UC) is an incurable chronic inflammation of the enteric tract. The aim of this study was to investigate the protective effects of arabinogalactan fromon DSS-induced chronic colitis. A homogeneous arabinogalactan was isolated and purified from, named LBP-3, which mainly consisted of arabinose and galactose with a molar ratio of 1.00 : 0.82. LBP-3 treatment remarkably alleviated body weight loss, histopathological damage and the overproduction of pro-inflammatory cytokines and enzymes in UC mice. Additionally, the intestinal barrier integrity was partially recovered by the up-regulated expression ofand tight junction proteins. Moreover, the gut microbiota shift was reversed by LBP-3 administration by enriching potential probiotic bacteria (, Ruminococcaceae) and inhibiting the proliferation of harmful bacteria (, Enterobacteriaceae). Furthermore, SCFAs, as major metabolites of LBP-3 fermentation by gut microbiota, were also promoted so as to maintain relatively favorable intestinal homeostasis. Overall, our findings suggested LBP-3 fromcould be a potential therapeutic candidate against UCimproving intestinal barrier function and partially restoring gut microbiota and its metabolites.

Study Type : Animal Study

Print Options

Key Research Topics

Sayer Ji
Founder of GreenMedInfo.com

Subscribe to our informative Newsletter & get Nature's Evidence-Based Pharmacy

Our newsletter serves 500,000 with essential news, research & healthy tips, daily.

Download Now

500+ pages of Natural Medicine Alternatives and Information.

This website is for information purposes only. By providing the information contained herein we are not diagnosing, treating, curing, mitigating, or preventing any type of disease or medical condition. Before beginning any type of natural, integrative or conventional treatment regimen, it is advisable to seek the advice of a licensed healthcare professional.

© Copyright 2008-2022 GreenMedInfo.com, Journal Articles copyright of original owners, MeSH copyright NLM.