Abstract Title:

Integrated in silico and experimental methods revealed that Arctigenin inhibited angiogenesis and HCT116 cell migration and invasion through regulating the H1F4A and Wnt/β-catenin pathway.

Abstract Source:

Mol Biosyst. 2015 Aug 12. Epub 2015 Aug 12. PMID: 26267229

Abstract Author(s):

Shouyue Zhang, Jie Li, Sicheng Song, Jing Li, Rongsheng Tong, Zhihe Zang, Qinglin Jiang, Lulu Cai

Article Affiliation:

Shouyue Zhang


Arctigenin (ARG) has been previously reported to exert diverse biological activities including anti-proliferation, anti-inflammatory, and antiviral, etc. In the current study, the anti-metastasis and anti-angiogenesis activities of ARG were investigated. To further understand how ARG played these bioactivities, proteomic approaches were used to profile the proteome changes in response to ARG treatment using 2DE-MS/MS. Using these approaches, a total of 50 differentially expressed proteins were identified and clustered. Bioinformatics analysis suggested that multiple signalling pathways were involved. Moreover, ARG induced anti-metastatic and anti-angiogenesis activities were mainly accompanied by a deactivation of the Wnt/β-catenin pathway in HCT116 cells.

Study Type : In Vitro Study

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