Use of Arctium lappa Extract Against Acetaminophen-Induced Hepatotoxicity in Rats.
Curr Ther Res Clin Exp. 2015 Dec ;77:73-8. Epub 2015 May 27. PMID: 26543508
Attalla Farag El-Kott
BACKGROUND: Severe destructive hepatic injuries can be induced by acetaminophen overdose and may lead to acute hepatic failure.
OBJECTIVE: To investigate the ameliorative effects of Arctium lappa root extract on acetaminophen-induced hepatotoxicity.
METHODS: Rats were divided into 4 groups: normal control group, Arctium lappa extract group, acetaminophen-injected group, and acetaminophen treated with Arctium lappa extract group.
RESULTS: The treatment with Arctium lappa extract reduced serum alanine transaminase, aspartate aminotransferase, and alkaline phosphatase in the acetaminophen group when compared with the control group. DNA fragments in the acetaminophen-injected group were also significantly increased (P<0.05). The comet assay revealed increased detaching tail length and DNA concentration during the hepatic toxicity in the acetaminophen group. The malondialdehyde content was inhibited by Arctium lappa treatment (12.97±0.89 nmol/mg) when compared with the acetaminophen-treated-only group (12.97±0.89 nmol/mg). Histopathologic examination revealed that acetaminophen administration produced hepatic cell necrosis, infiltrate of lymphocytes, and vacuolation that were associated with the acetaminophen-treated animalgroup, but the degree of acetaminophen-induced hepatotoxicity was mediated by treatment with Arctium lappa extract.
CONCLUSIONS: Arctium lappa can prevent most of the hepatic tissue damage caused by acetaminophen overdose in rats.