Abstract Title:

Effect of the oral administration homeopathic Arnica montana on mitochondrial oxidative stress.

Abstract Source:

Homeopathy. 2013 Jan ;102(1):49-53. PMID: 23290879

Abstract Author(s):

Ronaldo Antônio de Camargo, Ellen Dias da Costa, Rosana Catisti

Article Affiliation:

Ronaldo Antônio de Camargo


OBJECTIVE: To analyze the effect of homeopathic Arnica on mitochondrial oxidative stress induced by Ca(2+) plus inorganic phosphate and/or Fe(2+)-citrate-mediated lipid peroxidation through changes in oxygen consumption rates.

METHODS: Mitochondria were isolated by differential centrifugation from the livers of adult male Wistar rats which had been treated with Arnica montana 6cH, 12cH, 30cH or succussed 30% ethanol (control) for 21 days.

RESULTS: In the presence of antimycin-A, electron transport chain inhibitor, as evidenced by antimycin-A insensitive O(2) consumption, Arnica inhibited lipid peroxidation of mitochondrial membranes. In oxidative stress conditions, in the presence of Ca(2+) and inorganic phosphate, animals receiving Arnica 30cH had a significant decrease in mitochondrial O(2) consumption compared to control animals.

CONCLUSION: When administrated orally, Arnica 30cH protects against hepatic mitochondrial membrane permeabilization induced by Ca(2+) and/or Fe(2+)-citrate-mediated lipid peroxidation and fragmentation of proteins due to the attack by reactive oxygen species.

Study Type : Animal Study

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