Abstract Title:

Fertility in male rats: Disentangling adverse effects of arsenic compounds.

Abstract Source:

Reprod Toxicol. 2018 06 ;78:130-140. Epub 2018 Apr 24. PMID: 29702248

Abstract Author(s):

Graziela Domingues de Almeida Lima, Marcela Nascimento Sertorio, Ana Cláudia Ferreira Souza, Tatiana Prata Menezes, Viviane Gorete Silveira Mouro, Nayara Magalhães Gonçalves, Jerusa Maria de Oliveira, Marc Henry, Mariana Machado-Neves

Article Affiliation:

Graziela Domingues de Almeida Lima


Arsenic impairs male reproductive functions. However, it is not clear whether different arsenic compounds similarly affect fertility. In this study, we compared the impact of sodium arsenite and arsenate on sperm quality and fertility. After 56 d exposure, male Wistar rats were mated and pregnant females were evaluated by fertility indexes. Clearly, exposure to 10 mg/L arsenite reduced daily sperm production via HOoverproduction and germ cells loss. Animals from this group also showed a decrease in epididymal sperm counts and percentage of sperm with intact membranes. Moreover, they presented low fertility potential and high preimplantation loss. In contrast, 10 mg/L arsenate caused oxidative stress in testis, mineral imbalance in epididymis, and sperm membranes damage, with no effects on fertility. Both arsenic compounds at 0.01 mg/L altered reproductive parameters. We concluded that arsenite is more harmful than arsenate to sperm quality and male fertility, with negative influences in early pregnancy.

Study Type : Animal Study

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