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Abstract Title:

Artemisinin exerts a protective effect in the MPTP mouse model of Parkinson's disease by inhibiting microglial activation via the TLR4/Myd88/NF-KB pathway.

Abstract Source:

CNS Neurosci Ther. 2023 Jan 24. Epub 2023 Jan 24. PMID: 36691817

Abstract Author(s):

Jing Lv, Jing Zhu, Peihan Wang, Tongyu Liu, Jiang Yuan, Huan Yin, Yiran Lan, Qiang Sun, Zhifeng Zhang, Guoda Ding, Chenxi Zhou, Huajie Wang, Zihan Wang, Yunfu Wang

Article Affiliation:

Jing Lv

Abstract:

AIMS: We performed cell and animal experiments to explore the therapeutic effect of artemisinin on Parkinson's disease (PD) and the TLR4/Myd88 signaling pathway.

METHODS: C57 mice were randomly divided into the blank, 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-induced and artemisinin-treated groups. Clinical symptoms, the number of dopaminergic (DAergic) neurons in the substantia nigra, and microglial cell activation were compared among the three groups. Subsequently, BV-2 cell activation and TLR4/Myd88 pathway component expression were compared among the blank, MPP-treated, artemisinin-treated, and TLR4 activator-treated groups.

RESULTS: Behavioral symptoms were improved, the number of DAergic neurons in the substantia nigra of the midbrain was increased, and microglial cell activation was decreased in artemisinin-treated MPTP-induced PD model mice compared with control-treated MPTP-induced PD model mice (p < 0.05). The cell experiments revealed that artemisinin treatment reduced MPP-induced BV-2 cell activation and inhibited the TLR4/Myd88 signaling pathway. Moreover, the effect of artemisinin on the BV-2 cell model was inhibited by the TLR4 activator LPS (p < 0.05).

CONCLUSION: Artemisinin may reduce damage to DAergic neurons in a PD mouse model by decreasing microglial activation through the TLR4-mediated MyD88-dependent signaling pathway. However, this finding cannot explain the relationship between microglia and DAergic neurons.

Study Type : Animal Study

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