Vitamin C Deficiency and the Risk of Osteoporosis in Patients with an Inflammatory Bowel Disease.
Nutrients. 2020 Jul 29 ;12(8). Epub 2020 Jul 29. PMID: 32751086
Alicja Ewa Ratajczak
Recent research studies have shown that vitamin C (ascorbic acid) may affect bone mineral density and that a deficiency of ascorbic acid leads to the development of osteoporosis. Patients suffering from an inflammatory bowel disease are at a risk of low bone mineral density. It is vital to notice that patients with Crohn's disease and ulcerative colitis also are at risk of vitamin C deficiency which is due to factors such as reduced consumption of fresh vegetables and fruits, i.e., the main sources of ascorbic acid. Additionally, some patients follow diets which may provide an insufficient amount of vitamin C. Moreover, serum vitamin C level also is dependent on genetic factors, such asandgenes, encoding sodium-dependent vitamin C transporters and,andgenes which encode glutathione S-transferases. Furthermore, ascorbic acid may modify the composition of gut microbiota which plays a role in the pathogenesis of an inflammatory bowel disease.