Article Publish Status: FREE
Abstract Title:

Ascorbic acid metabolites are involved in intraocular pressure control in the general population.

Abstract Source:

Redox Biol. 2018 Oct 13 ;20:349-353. Epub 2018 Oct 13. PMID: 30391827

Abstract Author(s):

Pirro G Hysi, Anthony P Khawaja, Cristina Menni, Bani Tamraz, Nick Wareham, Kay-Tee Khaw, Paul J Foster, Leslie Z Benet, Tim D Spector, Chris J Hammond

Article Affiliation:

Pirro G Hysi


Elevated intraocular pressure (IOP) is an important risk factor for glaucoma. Mechanisms involved in its homeostasis are not well understood, but associations between metabolic factors and IOP have been reported. To investigate the relationship between levels of circulating metabolites and IOP, we performed a metabolome-wide association using a machine learning algorithm, and then employing Mendelian Randomization models to further explore the strength and directionality of effect of the metabolites on IOP. We show that O-methylascorbate, a circulating Vitamin C metabolite, has a significant IOP-lowering effect, consistent with previous knowledge of the anti-hypertensive and anti-oxidative role of ascorbate compounds. These results enhance understanding of IOP control and may potentially benefit future IOP treatment and reduce vision loss from glaucoma.

Study Type : Human Study

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