Article Publish Status: FREE
Abstract Title:

Ascorbic acid serum levels are reduced in patients with hematological malignancies.

Abstract Source:

Results Immunol. 2016 ;6:8-10. Epub 2016 Jan 12. PMID: 27014565

Abstract Author(s):

Mirelle J A J Huijskens, Will K W H Wodzig, Mateusz Walczak, Wilfred T V Germeraad, Gerard M J Bos

Article Affiliation:

Mirelle J A J Huijskens


In this paper we demonstrate that patients treated with chemotherapy and/or hematopoietic stem cell transplantation (HSCT) have highly significant reduced serum ascorbic acid (AA) levels compared to healthy controls. We recently observed in in vitro experiments that growth of both T and NK cells from hematopoietic stem cells is positively influenced by AA. It might be of clinical relevance to study the function and recovery of immune cells after intensive treatment, its correlation to AA serum levels and the possible effect of AA supplementation.

Study Type : In Vitro Study

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