Asparagus contains steroidal phytochemicals capable of irreversibly inhibiting DNA synthesis in human leukemia HL-60 cell in culture. - GreenMedInfo Summary

Abstract Title:

Steroidal saponins from Asparagus officinalis and their cytotoxic activity.

Abstract Source:

Planta Med. 1997 Jun;63(3):258-62. PMID: 9225609

Abstract Author(s):

Y Shao, O Poobrasert, E J Kennelly, C K Chin, C T Ho, M T Huang, S A Garrison, G A Cordell

Abstract:

Two oligofurostanosides were isolated from the seeds of Asparagus officinalis L and their structures characterized as 3-O-[alpha-L-rhamnopyranosyl-(1-->2)-(alpha-L-rhamnopyranosyl- (1-->4))-beta-D-glucopyranosyl]-26-O-[beta-D-glucopyranosyl]-(25R) -22 alpha-methoxyfurost-5-ene-3 beta,26-diol(methyl protodioscin) and its corresponding 22 alpha-hydroxy analogue (protodioscin). The structural identification was performed using detailed analysis of 1H- and 13C-NMR spectra including two-dimensional NMR spectroscopy (COSY, HMQC, NOESY and HMBC), and chemical conversions. These two compounds have been shown to inhibit the growth of human leukemia HL-60 cells in culture and macromolecular synthesis in a dose-dependent manner. The inhibitory effect on DNA synthesis was found to be irreversible.

Article Published Date : Jun 01, 1997
Study Type : In Vitro Study
Additional Links
Substances : Asparagus : CK(55) : AC(31)
Diseases : Leukemia : CK(2094) : AC(910), Promyelocytic leukemia : CK(163) : AC(138)

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Key Research Topics

Substance

Asparagus

Disease

Leukemia
Promyelocytic leukemia

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