Abstract Title:

Results of long-term carcinogenicity bioassay on Sprague-Dawley rats exposed to aspartame administered in feed.

Abstract Source:

Ann N Y Acad Sci. 2006 Sep;1076:559-77. PMID: 17119233

Abstract Author(s):

Fiorella Belpoggi, Morando Soffritti, Michela Padovani, Davide Degli Esposti, Michelina Lauriola, Franco Minardi

Article Affiliation:

Cesare Maltoni Cancer Research Center, European Foundation of Oncology and Environmental Sciences B. Ramazzini, 40010 Bentivoglio, Bologna, Italy.


Aspartame (APM) is one of the most widely used artificial sweeteners in the world. Its ever-growing use in more than 6000 products, such as soft drinks, chewing gum, candy, desserts, etc., has been accompanied by rising consumer concerns regarding its safety, in particular its potential long-term carcinogenic effects. In light of the inadequacy of the carcinogenicity bioassays performed in the 1970s and 1980s, a long-term mega-experiment on APM was undertaken at the Cesare Maltoni Cancer Research Center of the European Ramazzini Foundation on groups of male and female Sprague-Dawley rats (100-150/sex/group), 8 weeks old at the start of the experiment. APM was administered in feed at concentrations of 100,000, 50,000, 10,000, 2,000, 400, 80, or 0 ppm. Treatment lasted until spontaneous death of the animals. The results of the study demonstrate that APM causes: (a) an increased incidence of malignant tumor-bearing animals, with a positive significant trend in both sexes, and in particular in females treated at 50,000 ppm (P

Study Type : Animal Study

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